反应详情

Sodium hydride (50% w/w dispersion in oil; 0.114 g.) was added portionwise to ethanol (2 ml.). To the resulting solution was added 2-aminoethanethiol hydrochloride (0.134 g.) and the mixture stirred at room temperature. 2-[2-(2,2,2-Trifluoroethyl)guanidino]-6-chloropyrazine (0.1 g.) was added and the mixture heated under reflux on a steam bath for 22 hours. The mixture was cooled, evaporated, water added and extracted with ethyl acetate. The extracts were dried over magnesium sulphate, filtered and the filtrate evaporated to yield 2-[2-(2,2,2-trifluoroethyl)guanidino]-6-[(2-aminoethyl)thio]pyrazine as a gum (0.16 g.) which was used without further purification.

1. temperaturethe mixture heated
2. temperatureunder reflux on a steam bath for 22 hours
3. temperatureThe mixture was cooled
4. customevaporated
5. additionwater added
6. extractionextracted with ethyl acetate
7. dry with materialThe extracts were dried over magnesium sulphate
8. filtrationfiltered
9. customthe filtrate evaporated