HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 1-(3-Chloromethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178512201 | HCID 178512201 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(3-Chloromethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine | HCID 178512200 | — |
Reaction Steps
The above guanidine (1.121 g.) was dissolved in dry tetrahydrofuran (40 ml.) and thionyl chloride (0.7 ml.) was added. After 45 minutes at 30°-40° volatile material was evaporated in vacuo to give 1-(3-chloromethylphenyl)-3-(2,2,2-trifluoroethyl)guanidine as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04604465 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-658b7a21b2554068815983e12a10ee31 |
| Source note | uspto-grants-1986_08 |