1-Methylpiperazine → HCID 70430055, compound

HRID 364347Notes

Reaction equation

HRID 364347 reaction equation
ClC1C(Cl)=C2C(CC(C3CCCC3)(C)C2=O)=CC=1CC(N)=O.ClC1C(Cl)=C2C(CC(C3CCCC3)(C)C2=O)=CC=1OCCC(N)=O.[Cl:47][C:48]1[C:56]([Cl:57])=[C:55]2[C:51]([CH2:52][C:53]([CH:60]3[CH2:64][CH2:63][CH2:62][CH2:61]3)([CH3:59])[C:54]2=[O:58])=[CH:50][C:49]=1[O:65][CH2:66][C:67]1[C:68](=[O:74])[NH:69][C:70](=[O:73])[C:71]=1[OH:72].[CH3:75][N:76]1[CH2:81][CH2:80][NH:79][CH2:78][CH2:77]1>>[CH3:75][N:76]1[CH2:81][CH2:80][NH:79][CH2:78][CH2:77]1.[Cl:47][C:48]1[C:56]([Cl:57])=[C:55]2[C:51]([CH2:52][C:53]([CH:60]3[CH2:61][CH2:62][CH2:63][CH2:64]3)([CH3:59])[C:54]2=[O:58])=[CH:50][C:49]=1[O:65][CH2:66][C:67]1[C:68](=[O:74])[NH:69][C:70](=[O:73])[C:71]=1[OH:72]

Participants

5

Reactant 4

HCID 531671-MethylpiperazineHCID 13030807HCID 13030807, compoundHCID 20193614HCID 20193614, compoundHCID 70430056HCID 70430056, compound

Product 1

HCID 70430055HCID 70430055, compound

Procedure

The reaction is conducted as described in Example 1, Step D except that the (+)-(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)acetamide is replaced by an equimolar amount of 3-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxy]propanamide. There is thus obtained 3-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)oxymethyl]-4-hydroxy-1H-pyrrole-2,5-dione and its 1-methylpiperazine salt.

Sources & evidence

ORD record
ord-7c6de8bf5ebb438c9597d3583e9ecdec
Source dataset
uspto-grants-1986_08
Patent number
US04604403

Reaction notes

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