HCID 19938135, compound → N-{2-[Bis(4-hydroxyphenyl)methyl]phenyl}-4-aminobenzamide

HRID 36446Notes

Reaction equation

HRID 36446 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:27]2[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=2)=[CH:4][CH:3]=1>CO.[C].[Pd]>[OH:33][C:30]1[CH:31]=[CH:32][C:27]([CH:8]([C:5]2[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)=[CH:28][CH:29]=1

Participants

4

Reactant 1

HCID 19938135HCID 19938135, compound

Product 1

HCID 19938096N-{2-[Bis(4-hydroxyphenyl)methyl]phenyl}-4-aminobenzamideYield 38.4%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

In 50 ml of methanol were suspended 1.48 g of Compound 117 obtained by Example 117 and 0.23 g of 10% palladium-carbon, and the suspension was stirred under hydrogen atmosphere at room temperature for 2 hours. After the reaction was completed, the reaction mixture was filtered by using a filter aid. The solvent was evaporated under reduced pressure to afford 0.53 g of the desired compound (Compound 136).

Workup

  1. filtrationthe reaction mixture was filtered
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-83c9c889211b4610b50da3a3d18c1597
Source dataset
uspto-grants-1995_05
Patent number
US05413997

Reaction notes

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