反应详情

This example serves to illustrate procedure B of Scheme 2. To an ice-cooled solution of 1-(2-pyrimidinyl)piperazine (16.4 g, 0.1 mole) in 1N HCl (100 mL) was added dropwise bromine (15.98 g, 0.1 mole). After stirring at 0° for 0.5 hr, the mixture was heated to 100° until dissipation of the red color had occurred. The mixture is filtered, cooled, made alkaline with 50% NaOH and extracted with ether. The dried extract (MgSO4) was concentrated in vacuo to provide 14.5 g (62%) of product, m.p. 73°-75°.

1. temperaturethe mixture was heated to 100° until dissipation of the red color
2. filtrationThe mixture is filtered
3. temperaturecooled
4. extractionextracted with ether
5. extractionThe dried extract (MgSO4)
6. concentrationwas concentrated in vacuo