O-Methylhydroxylamine hydrochloride → HCID 86740953, compound

HRID 364626Notes

Reaction equation

HRID 364626 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1.Cl.[CH3:18][O:19][NH2:20]>N1C=CC=CC=1>[CH3:18][O:19][N:20]=[C:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[CH2:9][C:10]1[CH:15]=[N:14][CH:13]=[CH:12][N:11]=1

Participants

4

Reactant 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 20239487HCID 20239487, compound

Product 1

HCID 86740953HCID 86740953, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3 g of 2'-chloro-2-(2-pyrazinyl)-acetophenone and 0.8 g of O-methylhydroxylamine hydrochloride are dissolved in 10 ml of pyridine and the mixture is heated at 80° for 30 minutes. The pyridine is then removed under reduced pressure and water is added to the crude product. Thereupon, the mixture is extracted with ethyl acetate and the organic phase is dried over sodium sulfate and concentrated to yield 2'-chloro-2-(2-pyrazinyl)-acetophenone O-methyl oxime as an oil.

Workup

  1. temperaturethe mixture is heated at 80° for 30 minutes
  2. customThe pyridine is then removed under reduced pressure and water
  3. additionis added to the crude product
  4. extractionThereupon, the mixture is extracted with ethyl acetate
  5. dry with materialthe organic phase is dried over sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-d5aab528030d4a7dad87221b8528c5fb
Source dataset
uspto-grants-1986_08
Patent number
US04605656

Reaction notes

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