反应详情

To a stirred mixture of ethyl 4-aminobutanoate hydrochloride (3.4 g) and phenoxyacetyl chloride (2.76 ml) in 50 ml of Et2O and 50 ml of water was added one portion of NaHCO3 (4.2 g). After 2 hr the layers were separated and the organic phase was washed (1N HCl, brine), dried (MgSO4), and filtered. Evaporation of the solvent under vacuum gave 3.1 g (53%) of the title compound as an oil.

1. customAfter 2 hr the layers were separated
2. washthe organic phase was washed (1N HCl, brine)
3. dry with materialdried (MgSO4)
4. filtrationfiltered
5. customEvaporation of the solvent under vacuum