反应详情

A mixture of benzyl amine (10.7 g) and succinic anhydride (10 g) was stirred in THF (1 liter) for 2 days. The solid was filtered and dissolved in 1N NaOH (110 ml). The aqueous phase was washed with Et2O and then made acidic with conc HCl while cooling in an ice-water bath. The solid was collected, washed with water and dried under high vacuum. There was obtained 10.9 g (53%) of the title compound as a white powder m. p. 137.5°-138°.

1. filtrationThe solid was filtered
2. dissolutiondissolved in 1N NaOH (110 ml)
3. washThe aqueous phase was washed with Et2O
4. temperaturewhile cooling in an ice-water bath
5. customThe solid was collected
6. washwashed with water
7. customdried under high vacuum