Lawesson's reagent → HCID 13712238, compound

HRID 364881Notes

Reaction equation

HRID 364881 reaction equation
[CH3:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[F:16])=O)=[CH:4][CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:28])=CC=1>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:18]=[CH:17][C:5]([C:6](=[S:28])[NH:8][C:9]2[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=2[F:16])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 7770291HCID 7770291, compound

Product 1

HCID 13712238HCID 13712238, compoundYield 149.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

36.7 g of 4-methyl-2',5'-difluorobenzanilide was dissolved in 170 ml of toluene, and 36 g of Lawesson's reagent was added. The mixture was refluxed for 1 hour. The reaction mixture was evaporated to dryness under reduced pressure. The residue was recrystallized from 100 ml of benzene to give 35.0 g of the captioned compound as yellow needle-like crystals.

Workup

  1. temperatureThe mixture was refluxed for 1 hour
  2. customThe reaction mixture was evaporated to dryness under reduced pressure
  3. customThe residue was recrystallized from 100 ml of benzene

Sources & evidence

ORD record
ord-5631ecf68caf437ba0de47d156a3f6d2
Source dataset
uspto-grants-1986_08
Patent number
US04607031

Reaction notes

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