Pyrrolidine → 2-Aminomethyl-4-(1,1-dimethylethyl)-6-(1-pyrrolidinylsulfonyl)-phenol hydrochloride

HRID 364904Notes

Reaction equation

C([NH:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[CH:9]=[C:8]([S:16]([Cl:19])(=[O:18])=[O:17])[C:7]=1[OH:20])(=O)C.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[ClH:19].[NH2:4][CH2:5][C:6]1[CH:11]=[C:10]([C:12]([CH3:13])([CH3:14])[CH3:15])[CH:9]=[C:8]([S:16]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)(=[O:17])=[O:18])[C:7]=1[OH:20]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 132103492-Acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol

Product 1

HCID 212969072-Aminomethyl-4-(1,1-dimethylethyl)-6-(1-pyrrolidinylsulfonyl)-phenol hydrochloride

Procedure

This compound is prepared analogously to Examples 11c and 11d from 2-acetamidomethyl-6-chlorosulfonyl-4-(1,1-dimethylethyl)-phenol and pyrrolidine.

Sources & evidence

ORD record: ord-3ae3c3fe14814a879f7a7b049ec03be3
Source dataset: uspto-grants-1986_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04607030

Reaction notes

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