反应详情

A mixture of o-aminoacetophenone (25 g.) and phenylacetic acid (25 g.) in anhydrous methylene dichloride (200 ml.) was prepared. To that mixture was added dicyclohexylcarbodiimide (40 g.) in portions of approx. 10 g. every 5 min. at ambient temperature. When the addition was completed the mixture was stirred for 4 hr. at ambient temperature. The mixture was then filtered, and the filtrate was evaporated in vacuo to dryness. The residue was crystallised from cyclohexane to give o-acetyl-N-(phenylacetyl)aniline, m.p. 78°.

1. customwas prepared
2. customevery 5 min.
3. customat ambient temperature
4. additionWhen the addition
5. customat ambient temperature
6. filtrationThe mixture was then filtered
7. customthe filtrate was evaporated in vacuo to dryness
8. customThe residue was crystallised from cyclohexane