反应详情

A mixture of 4-methyl-3-phenylquinolin-2-one (1.18 g.) and phosphorus oxychloride (60 ml.) was heated under reflux for 2 hr. The mixture was cooled and poured into ice-water (200 ml.), and the resulting mixture was extracted with ethyl acetate (3×50 ml.). The ethyl acetate extract was washed successively with saturated sodium carbonate solution (3×50 ml.) and water (50 ml.), dried (Na2SO4), and evaporated in vacuo to dryness. The residue was crystallised from cyclohexane to give 2-chloro-4-methyl-3-phenylquinoline, m.p. 88°-90°.

1. temperaturewas heated
2. temperatureunder reflux for 2 hr
3. temperatureThe mixture was cooled
4. extractionthe resulting mixture was extracted with ethyl acetate (3×50 ml.)
5. extractionThe ethyl acetate extract
6. washwas washed successively with saturated sodium carbonate solution (3×50 ml.) and water (50 ml.)
7. dry with materialdried (Na2SO4)
8. customevaporated in vacuo to dryness
9. customThe residue was crystallised from cyclohexane