HCID 70040791, compound → HCID 70455662, compound

HRID 364929Notes

Reaction equation

HRID 364929 reaction equation
[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:18]=[CH:17][C:11]([CH:12]=[CH:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1>CC(C)=O>[OH2:15].[ClH:1].[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]1[CH:18]=[CH:17][C:11]([CH:12]=[CH:13][C:14]([OH:16])=[O:15])=[CH:10][CH:9]=1

Participants

3

Reactant 1

HCID 70040791HCID 70040791, compound

Product 1

HCID 70455662HCID 70455662, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

4-(1-Imidazolylmethyl)cinnamic acid hydrochloride is dissolved by heating in an adequate amount of 50% (V/V%) aqueous acetone and filtrated and the filtrate is diluted with acetone in an amount sufficient to make an aqueous solution of acetone having water content of about 10-30% (V/V%), preferably about 17% (V/V%). The mixture is allowed to stand at room temperature for an adequate period of time. The precipitates are collected and dried under reduced pressure at room temperature to obtain 4-(1-imidazolylmethyl)cinnamic acid hydrochloride monohydrate.

Workup

  1. filtrationfiltrated
  2. additionthe filtrate is diluted with acetone in an amount sufficient
  3. waitto stand at room temperature for an adequate period of time
  4. customThe precipitates are collected
  5. customdried under reduced pressure at room temperature

Sources & evidence

ORD record
ord-5b6a1a8fbee445c2a8fc99638bf58cf5
Source dataset
uspto-grants-1986_08
Patent number
US04607046

Reaction notes

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