Acetonitrile → HCID 86739957, compound

HRID 364935Notes

Reaction equation

HRID 364935 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1.CO[CH:14](OC)[N:15]([CH3:17])[CH3:16].[C:20](#N)C>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH:20]=[CH:14][N:15]([CH3:17])[CH3:16])[C:9](=[O:11])[CH3:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 78373Dimethylformamide dimethyl acetalHCID 521187(4-Fluorophenyl)acetone

Product 1

HCID 86739957HCID 86739957, compound

Procedure

A mixture of 4-fluorophenyl acetone (50 grams) and 162.5 ml of N,N-dimethylformamide dimethyl acetal in 75 ml of acetonitrile is stirred for 12 hours and then the reaction mixture is concentrated on a rotary evaporator. The residual solid is suspended in 100 ml of hexane and filtered to give 59.6 grams of 1-(4-fluorophenyl)-2-(dimethylamino)ethenyl-2-propanone.

Workup

  1. concentrationthe reaction mixture is concentrated on a rotary evaporator
  2. filtrationfiltered

Sources & evidence

ORD record
ord-e8eb8fe17acd4e3fb29cc6ed6ea92e95
Source dataset
uspto-grants-1986_08
Patent number
US04607037

Reaction notes

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