HCID 178455973, compound → HCID 178455964, compound

HRID 365056Notes

Reaction equation

HRID 365056 reaction equation
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:22]([NH:24][C@H:25]([C:36]([NH:38][C@H:39]([C:44]([NH:46][CH2:47][C:48]([O:50][CH3:51])=[O:49])=[O:45])[C@H:40]([CH2:42][CH3:43])[CH3:41])=[O:37])[CH2:26][CH2:27][CH2:28][NH:29][C:30](=[NH:35])[NH:31][N+:32]([O-:34])=[O:33])=[O:23])[CH2:11][C:12](=[O:21])[O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]>CCOC(C)=O>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:22]([NH:24][C@H:25]([C:36]([NH:38][C@H:39]([C:44]([NH:46][CH2:47][C:48]([O:50][CH3:51])=[O:49])=[O:45])[C@H:40]([CH2:42][CH3:43])[CH3:41])=[O:37])[CH2:26][CH2:27][CH2:28][NH:29][C:30](=[NH:35])[NH:31][N+:32]([O-:34])=[O:33])=[O:23])[CH2:11][C:12](=[O:21])[O:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]

Participants

3

Reactant 1

HCID 178455973HCID 178455973, compound

Product 1

HCID 178455964HCID 178455964, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A sample of the pentapeptide (12) suspended in EtOAc is treated exactly as described for the preparation of tetrapeptide HCl salt (11) to give product (13).

Workup

  1. additionis treated exactly

Sources & evidence

ORD record
ord-030d3c5b0fed4572b25e2d7bb441dc9c
Source dataset
uspto-grants-1986_08
Patent number
US04607023

Reaction notes

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