HRID365056

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)N[C@H](C(=O)NCC(=O)OC)[C@@H](C)CC

HCID178455973

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)N[C@H](C(=O)NCC(=O)OC)[C@@H](C)CC

HCID178455964

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A sample of the pentapeptide (12) suspended in EtOAc is treated exactly as described for the preparation of tetrapeptide HCl salt (11) to give product (13).

WORKUP

后处理

additionis treated exactly

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-030d3c5b0fed4572b25e2d7bb441dc9c
来源数据集: uspto-grants-1986_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04607023
来源说明: uspto-grants-1986_08

反应 SMILES

[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:7]([NH:9][C@H:10]([C:22]([NH:24][C@H:25]([C:36]([NH:38][C@H:39]([C:44]([NH:46][CH2:47][C:48]([O:50][CH3:51])=[O:49])=[O:45])[C@H:40]([CH2:42][CH3:43])[CH3:41])=[O:37])[CH2:26][CH2:27][CH2:28][NH:29][C:30](=[NH:35])[NH:31][N+:32]([O-:34])=[O:33])=[O:23])[CH2:11][C:12](=[O:21])[O:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]>CCOC(C)=O>[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:22]([NH:24][C@H:25]([C:36]([NH:38][C@H:39]([C:44]([NH:46][CH2:47][C:48]([O:50][CH3:51])=[O:49])=[O:45])[C@H:40]([CH2:42][CH3:43])[CH3:41])=[O:37])[CH2:26][CH2:27][CH2:28][NH:29][C:30](=[NH:35])[NH:31][N+:32]([O-:34])=[O:33])=[O:23])[CH2:11][C:12](=[O:21])[O:13][CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:8])[C@H:3]([CH2:5][CH3:6])[CH3:4]