HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178455932, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | HCID 178418300 | HCID 178418300 | — |
| Reactant | HCID 178454200 | HCID 178454200 | — |
| Reactant | HCID 178455973 | HCID 178455973 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178455932 | HCID 178455932 | — |
Reaction Steps
A sample HCl salt 13 and about 1.2 molar equivalents of Boc-Arg(NO2)-OH are mixed in DMF with N-methylmorpholine and hydroxybenztriazole; the solution is then treated with EDC and, after 3 h, the reaction is worked up exactly as described for pentapeptide (12) to give the compound (14) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04607023 |
| Source dataset | uspto-grants-1986_08 |
| ORD ID | ord-ac54e2083a16435e948bd6706871854e |
| Source note | uspto-grants-1986_08 |