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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 365057Generated: October 26, 2026

Hydrochloric Acid → HCID 178455932, compound

https://huagongshe.com/reaction/365057

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant4-MethylmorpholineHCID 7972—
ReactantHCID 178418300HCID 178418300—
ReactantHCID 178454200HCID 178454200—
ReactantHCID 178455973HCID 178455973—
Solvent1,2-DichloroethaneHCID 11—
SolventDimethylformamideHCID 6228—
ProductHCID 178455932HCID 178455932—

Reaction Steps

A sample HCl salt 13 and about 1.2 molar equivalents of Boc-Arg(NO2)-OH are mixed in DMF with N-methylmorpholine and hydroxybenztriazole; the solution is then treated with EDC and, after 3 h, the reaction is worked up exactly as described for pentapeptide (12) to give the compound (14) as a white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04607023
Source datasetuspto-grants-1986_08
ORD IDord-ac54e2083a16435e948bd6706871854e
Source noteuspto-grants-1986_08