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HRID365057

反应详情

EQUATION

反应方程式

HRID 365057 的结构方程式

REACTANTS

反应物

5
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

结构：Oc1cccc2[nH]nnc12
HCID178418300

未命名化合物

结构：CC(C)(C)OC(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O
HCID178454200

未命名化合物

结构：CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC(=O)OCc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)N[C@H](C(=O)NCC(=O)OC)[C@@H](C)CC
HCID178455973

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)[C@H](CC(=O)OCc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N[N+](=O)[O-])NC(=O)OC(C)(C)C)[C@@H](C)CC)C(=O)NCC(=O)OC
HCID178455932

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A sample HCl salt 13 and about 1.2 molar equivalents of Boc-Arg(NO2)-OH are mixed in DMF with N-methylmorpholine and hydroxybenztriazole; the solution is then treated with EDC and, after 3 h, the reaction is worked up exactly as described for pentapeptide (12) to give the compound (14) as a white solid.