Dimethylformamide dimethyl acetal → Ethyl 2-[2-(dimethylamino)vinyl]-5-nitronicotinate

Participants

Reaction Steps

A solution containing 20.88 g of ethyl 2-methyl-5-nitronicotinate in 100 mL 1,1-dimethoxytrimethylamine is heated at reflux for three hours and 15 minutes. The mixture is cooled and the solid collected by filtration, washed with methanol and air dried to give 26 g of the desired enamine as a dark red solid mp 176°-179° C.

Provenance & Evidence