反应详情

A solution containing 20.88 g of ethyl 2-methyl-5-nitronicotinate in 100 mL 1,1-dimethoxytrimethylamine is heated at reflux for three hours and 15 minutes. The mixture is cooled and the solid collected by filtration, washed with methanol and air dried to give 26 g of the desired enamine as a dark red solid mp 176°-179° C.

1. temperatureis heated
2. temperatureat reflux for three hours and 15 minutes
3. temperatureThe mixture is cooled
4. filtrationthe solid collected by filtration
5. washwashed with methanol and air
6. customdried