反应详情

3,4-Diethoxyaniline (1.8 g) and diethylaniline (1.5 g) were dissolved in benzene (20 ml). To the resultant solution was dropwise added isopropyl chloroformate (1.2 g) in 5 minutes under ice-cooling. After being allowed to stand at room temperatue for 3 hours, the reaction mixture was poured into ice-water and extracted with ether. The extract was washed with water, dried over magnesium sulfate and concentrated under reduced pressure to give crude crystals (2.6 g). Recrystallization from ethanol gave isopropyl N-(3,4-diethoxyphenyl)carbamate (Compound No. 13) (2.3 g) in a yield of 86%. M.P., 100°-100.5° C.

1. customin 5 minutes
2. temperaturecooling
3. extractionextracted with ether
4. washThe extract was washed with water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customto give crude crystals (2.6 g)
8. customRecrystallization from ethanol