反应详情

Malonic acid (7.5 g, 72.1 mmole) and 2-naphthaldehyde (5.0 g, 32.0 mmole) were dissolved in pyridine (20 mL) and refluxed for 1 hour. After cooling to room temperature, the reaction mixture was poured into 2N HCl solution (200 mL). The product precipitated immediately. It was collected by filtration and recrystallized from aqueous ethanol (200 mL ethanol/50 mL water) to give colorless needles (5.2 g, 82%).

1. temperaturerefluxed for 1 hour
2. customThe product precipitated immediately
3. filtrationIt was collected by filtration
4. customrecrystallized from aqueous ethanol (200 mL ethanol/50 mL water)