Cyanogen Bromide → HCID 13689355, compound

HRID 365134Notes

Reaction equation

HRID 365134 reaction equation
C([O-])([O-])=O.[K+].[K+].[N:7]#CBr.[CH3:10][N:11]1[CH2:16][CH2:15][CH:14]([CH:17]2[C:23]3=[CH:24][CH:25]=[CH:26][N:22]3[CH2:21][C:20]3[CH:27]=[CH:28][CH:29]=[CH:30][C:19]=3[O:18]2)[CH2:13][CH2:12]1>C(Cl)(Cl)Cl>[C:10]([N:11]1[CH2:16][CH2:15][CH:14]([CH:17]2[C:23]3=[CH:24][CH:25]=[CH:26][N:22]3[CH2:21][C:20]3[CH:27]=[CH:28][CH:29]=[CH:30][C:19]=3[O:18]2)[CH2:13][CH2:12]1)#[N:7]

Participants

5

Reactant 3

HCID 10476Cyanogen BromideHCID 11430Potassium CarbonateHCID 13689354HCID 13689354, compound

Product 1

HCID 13689355HCID 13689355, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

Milled K2CO3 (25 g, 0.18 mole) was added to a solution of cyanogen bromide (10.6 g, 0.1 mole) in 100 ml chloroform, and the mixture was heated to reflux and a solution of 11-[(1-methyl)piperidin-4-yl]-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (24 g, 0.085 mole) in 100 ml chloroform was added thereto over a period of one hour.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux

Sources & evidence

ORD record
ord-07a132da8ebc4f08ab2e41b4ab5ebf74
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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