HCID 13689392, compound → HCID 13689393, compound

HRID 365147Notes

Reaction equation

HRID 365147 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([CH:23]3[C:29]4=[CH:30][CH:31]=[CH:32][N:28]4[CH2:27][C:26]4[CH:33]=[CH:34][CH:35]=[CH:36][C:25]=4[O:24]3)[CH2:19][CH2:18]2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>[Pd].C(O)(C)C>[OH:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][CH:20]([CH:23]3[C:29]4=[CH:30][CH:31]=[CH:32][N:28]4[CH2:27][C:26]4[CH:33]=[CH:34][CH:35]=[CH:36][C:25]=4[O:24]3)[CH2:21][CH2:22]2)=[CH:11][CH:10]=1

Participants

5

Reactant 2

HCID 13689392HCID 13689392, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13689393HCID 13689393, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

To 200 ml isopropanol was added 11-{1-[2-(4-benzyloxyphenyl)-ethyl]piperidin-4-yl}-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (2.8 g, 0.006 mole) and 10% Pd/C (3.0 g). After shaking on a Parr apparatus under 50 psi of hydrogen for twenty-four hours, the solution was filtered and evaporated to a solid (2.2 g, m.p. 77° C.).

Workup

  1. filtrationthe solution was filtered
  2. customevaporated to a solid (2.2 g, m.p. 77° C.)

Sources & evidence

ORD record
ord-978bfda75207432db05840825fe6399b
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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