Dimethylformamide → HCID 20237869, compound

HRID 365202Notes

Reaction equation

HRID 365202 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[N:25]=[C:24]([NH2:26])[C:23]2[C:18](=[CH:19][C:20]([O:29][CH3:30])=[C:21]([O:27][CH3:28])[CH:22]=2)[N:17]=1.CN(C)C=O>O>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][NH:12][CH2:13][CH2:14][NH:15][C:16]1[N:25]=[C:24]([NH2:26])[C:23]2[C:18](=[CH:19][C:20]([O:29][CH3:30])=[C:21]([O:27][CH3:28])[CH:22]=2)[N:17]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 31217Phenyl glycidyl etherHCID 20237856HCID 20237856, compound

Product 1

HCID 20237869HCID 20237869, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3.8 g Phenyl glycidyl ether and 10 g. 2-(2-aminoethylamino)-4-amino-6,7-dimethoxyquinazoline are dissolved in 5 ml. dimethylformamide and left to stand for 48 hours at ambient temperature. The reaction mixture is then poured into water, filtered with suction and purified chromatographically on a silica gel column in the manner described in Example 24. There are obtained 2.5 g. (24% of theory) of the desired product in the form of colorless crystals; m.p. 122°-124° C., after recrystallization from isopropyl alcohol.

Workup

  1. filtrationfiltered with suction
  2. custompurified chromatographically on a silica gel column in the manner
  3. customThere are obtained 2.5 g

Sources & evidence

ORD record
ord-c4114e80e8234cccbafc2120fd85e67f
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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