Water → HCID 20237793, compound

Participants

Reaction Steps

4.5 g. Phenyl glycidyl ether and 14.2 g. 6-(2-aminoethylamino)-purine are stirred in 100 ml. dimethylformamide for 10 hours at 50° C. The reaction mixture is taken up in methylene chloride, shaken out with water, dried and purified chromatographically on a silica gel column in the manner described in Example 25. The product obtained by evaporation of the pure fractions is recrystallized from ethanol. There are obtained 2.3 g. (23% of theory) of the desired product in the form of colorless crystals; m.p. 169°-170° C., with bubble formation.

Provenance & Evidence