Water → HCID 20237793, compound

HRID 365212Notes

Reaction equation

HRID 365212 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH:2]1[O:4][CH2:3]1.[NH2:12][CH2:13][CH2:14][NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[NH:18][CH:19]=[N:20]2.CN(C)C=O.O>C(Cl)Cl>[O:5]([CH2:1][CH:2]([OH:4])[CH2:3][NH:12][CH2:13][CH2:14][NH:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[NH:18][CH:19]=[N:20]2)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 31217Phenyl glycidyl etherHCID 20237862HCID 20237862, compound

Product 1

HCID 20237793HCID 20237793, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4.5 g. Phenyl glycidyl ether and 14.2 g. 6-(2-aminoethylamino)-purine are stirred in 100 ml. dimethylformamide for 10 hours at 50° C. The reaction mixture is taken up in methylene chloride, shaken out with water, dried and purified chromatographically on a silica gel column in the manner described in Example 25. The product obtained by evaporation of the pure fractions is recrystallized from ethanol. There are obtained 2.3 g. (23% of theory) of the desired product in the form of colorless crystals; m.p. 169°-170° C., with bubble formation.

Workup

  1. customdried
  2. custompurified chromatographically on a silica gel column in the manner
  3. customThe product obtained by evaporation of the pure fractions
  4. customis recrystallized from ethanol
  5. customThere are obtained 2.3 g

Sources & evidence

ORD record
ord-9e390eb88d7c4a92a7f790a27616549e
Source dataset
uspto-grants-1986_08
Patent number
US04608383

Reaction notes

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