反应详情

温度

50 °C

To a solution of the above thiourea (1.59 g, 2.215 mmol) in ethanol (50 ml), 1 N hydrochloric acid (16 ml) was added and the reaction mixture was heated to 50° C. for 10 h. The cooled reaction mixture was washed with diethyl ether (3×30 ml) and the aqueous phase evaporated in vacuo. The residue was extracted with absolute ethanol (3×20 ml) and evaporated in vacuo followed by drying in vacuo affording 1.23 g (99%) of the title compound as an amorphous powder.

1. customThe cooled reaction mixture
2. washwas washed with diethyl ether (3×30 ml)
3. customthe aqueous phase evaporated in vacuo
4. extractionThe residue was extracted with absolute ethanol (3×20 ml)
5. customevaporated in vacuo
6. customby drying in vacuo