Hydrochloric Acid → HCID 178478904, compound

HRID 365283Notes

Reaction equation

HRID 365283 reaction equation
C1(C(C2C=CC=CC=2)(C2C=CC=CC=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH2:15][NH:16][C:17]([NH:19][CH2:20][CH2:21][CH2:22][N:23]([CH2:30][C:31]3[CH:36]=[CH:35][C:34]([Br:37])=[CH:33][CH:32]=3)[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=3)=[S:18])[N:10]=[CH:9]2)C=CC=CC=1.[ClH:50]>C(O)C>[ClH:50].[ClH:50].[Br:37][C:34]1[CH:33]=[CH:32][C:31]([CH2:30][N:23]([CH2:22][CH2:21][CH2:20][NH:19][C:17]([NH:16][CH2:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][NH:8][CH:12]=2)=[S:18])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][N:25]=2)=[CH:36][CH:35]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 221185151-[3-(1-triphenylmethylimidazol-4-yl)propyl]-3-[3-[N-(4-bromobenzyl)-N-(pyridin-2-yl)amino]propyl]thiourea

Product 1

HCID 178478904HCID 178478904, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To a solution of the above thiourea (1.59 g, 2.215 mmol) in ethanol (50 ml), 1 N hydrochloric acid (16 ml) was added and the reaction mixture was heated to 50° C. for 10 h. The cooled reaction mixture was washed with diethyl ether (3×30 ml) and the aqueous phase evaporated in vacuo. The residue was extracted with absolute ethanol (3×20 ml) and evaporated in vacuo followed by drying in vacuo affording 1.23 g (99%) of the title compound as an amorphous powder.

Workup

  1. customThe cooled reaction mixture
  2. washwas washed with diethyl ether (3×30 ml)
  3. customthe aqueous phase evaporated in vacuo
  4. extractionThe residue was extracted with absolute ethanol (3×20 ml)
  5. customevaporated in vacuo
  6. customby drying in vacuo

Sources & evidence

ORD record
ord-2afd8bc1919c47f4a3a39a297742a80b
Source dataset
uspto-grants-2000_10
Patent number
US06127343

Reaction notes

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