反应详情

The solution of the product of example 13 (1.50 g, 0.010 mol) and bis(2-chloroethyl)amine hydrochloride (1.77 g 0.01 mol) in chlorobenzene (20 ml) was heated under reflux for 24 h, cooled to room temperature and evaporated in vacuo. The white solid was dissolved in aqueous sodium hydroxide (100 ml) and extracted into ethyl acetate (3×50 ml). The extracts were dried (MgSO4) and evaporated in vacuo to give the product (2.00 g).

1. temperatureunder reflux for 24 h
2. customevaporated in vacuo
3. dissolutionThe white solid was dissolved in aqueous sodium hydroxide (100 ml)
4. extractionextracted into ethyl acetate (3×50 ml)
5. dry with materialThe extracts were dried (MgSO4)
6. customevaporated in vacuo