Sodium hydride → HCID 15481935, compound

HRID 365324Notes

Reaction equation

HRID 365324 reaction equation
[H-].[Na+].[CH:3]1[C:13]2[CH2:12][O:11][C:10]3[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=3[NH:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.Cl[C@@H:19]1[CH2:24][CH2:23][CH2:22][N:21]([CH2:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[CH:28]=2)[CH2:20]1>CS(C)=O>[CH3:34][O:33][C:29]1[CH:28]=[C:27]([CH:32]=[CH:31][CH:30]=1)[CH2:26][CH2:25][N:21]1[CH2:22][CH2:23][CH2:24][C@H:20]1[CH2:19][N:8]1[C:7]2[CH:6]=[CH:5][CH:4]=[CH:3][C:13]=2[CH2:12][O:11][C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]1=2

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 110847985,11-Dihydrodibenzo[b,e][1,4]oxazepineHCID 15481950HCID 15481950, compound

Product 1

HCID 15481935HCID 15481935, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Procedure

Sixty-percent sodium hydride (0.30 g, 7.5 mmols) was washed with petroleum ether, and then suspended in 30 ml of dimethyl sulfoxide. To the suspension were added 990 mg (5.0 mmols) of 5,11-dihydrodibenzo[b,e][1,4]oxazepine. The mixture was stirred in a nitrogen atmosphere at room temperature for 30 minutes. To this reaction solution was added dropwise a solution of 1.4 g (5.5 mmols) of (R)-(-)-3-chloro-1-(3-methoxyphenethyl)piperidine [[α]D25 =-8.9° (c=1.2, ethanol)] in 5 ml of dimethyl sulfoxide, and the mixed solution was stirred at room temperature for 12 hours and at 45° C. for 2.5 hours. The reaction solution was poured into ice water, and extracted with ethyl acetate. The organic layer was washed with water and with a saturated aqueous solution of sodium chloride in this order, and dried. Subsequently, the solvent was distilled off under reduced pressure. The resulting residue was subjected to column chromatography, and eluted with a mixed solvent of ethyl acetate and hexane at a ratio of 1:5. This mixed solvent was then distilled off under reduced pressure. The thus-obtained residue was further subjected to column chromatography, and eluted with a mixed solvent of chloroform and methanol at a ratio of 200:1. This mixed solvent was distilled off under reduced pressure to give 1.64 g of (S)-(-)-5,11-dihydro-5-[1-(3-methoxyphenethyl)-2-pyrrolidinylmethyl]-dibenzo[b,e][1,4]oxazepine as a pale yellow oil in a yield of 79%.

Workup

  1. stirringthe mixed solution was stirred at room temperature for 12 hours and at 45° C. for 2.5 hours
  2. extractionextracted with ethyl acetate
  3. washThe organic layer was washed with water and with a saturated aqueous solution of sodium chloride in this order
  4. customdried
  5. distillationSubsequently, the solvent was distilled off under reduced pressure
  6. washeluted with a mixed solvent of ethyl acetate and hexane at a ratio of 1:5
  7. distillationThis mixed solvent was then distilled off under reduced pressure
  8. washeluted with a mixed solvent of chloroform and methanol at a ratio of 200:1
  9. distillationThis mixed solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-98831d23ff7849b986ea6257f29e8d65
Source dataset
uspto-grants-2000_10
Patent number
US06127361

Reaction notes

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