HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (+)-5-[[(2R, 4S)-4-hydroxy-1-(4-methoxyphenethyl) pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo-[b,e][1,4]oxazepine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | (+)-5-[[(2R,4S)-4-hydroxy-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine | HCID 15481940 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (+)-5-[[(2R, 4S)-4-hydroxy-1-(4-methoxyphenethyl) pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo-[b,e][1,4]oxazepine hydrochloride | HCID 86755871 | 100% |
Reaction Steps
630 mg (1.46 mmol) of (+)-5-[[(2R,4S)-4-hydroxy-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine in 5 ml of dichloromethane was treated with 0.5 ml of ether saturated with hydrogen chloride and the mixture was concentrated in vacuo. the residue was recrystalized from acetone-ether to give 690 mg (100%) of (+)-5-[[(2R, 4S)-4-hydroxy-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine hydrochloride as colorless prisms.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127361 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-b1d25a32ab1b48d6871b0e3a1878acf3 |
| Source note | uspto-grants-2000_10 |