反应详情

630 mg (1.46 mmol) of (+)-5-[[(2R,4S)-4-hydroxy-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine in 5 ml of dichloromethane was treated with 0.5 ml of ether saturated with hydrogen chloride and the mixture was concentrated in vacuo. the residue was recrystalized from acetone-ether to give 690 mg (100%) of (+)-5-[[(2R, 4S)-4-hydroxy-1-(4-methoxyphenethyl)pyrrolidin-2-yl]methyl]-5,11-dihydrodibenzo[b,e][1,4]oxazepine hydrochloride as colorless prisms.

1. concentrationthe mixture was concentrated in vacuo
2. customthe residue was recrystalized from acetone-ether