HCID 23291342, compound → HCID 23291358, compound

HRID 365361Notes

Reaction equation

HRID 365361 reaction equation
[OH:1][CH2:2][C:3]1[N:8]=[CH:7][N:6]=[C:5]([O:9][CH2:10][CH2:11][CH3:12])[C:4]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=1[O:21][CH2:22][O:23][CH3:24]>C(Cl)Cl.O=[Mn]=O>[CH:2]([C:3]1[N:8]=[CH:7][N:6]=[C:5]([O:9][CH2:10][CH2:11][CH3:12])[C:4]=1[C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:14]=1[O:21][CH2:22][O:23][CH3:24])=[O:1]

Participants

4

Reactant 1

HCID 23291342HCID 23291342, compound

Product 1

HCID 23291358HCID 23291358, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of 6-hydroxymethyl-5-(2-methoxymethoxy-4-methoxyphenyl)-4-propoxy-pyrimidine in CH2Cl2 was treated with MnO2 and stirred vigorously for 24 h. The mixture was filtered through celite and concentrated to afford the title compound (1.48 g, 62%).

Workup

  1. filtrationThe mixture was filtered through celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b66188b427e747a894c8fb7b5465b345
Source dataset
uspto-grants-2000_10
Patent number
US06127371

Reaction notes

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