Ethanol → HCID 18665754, compound

HRID 365455Notes

Reaction equation

HRID 365455 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:9][O:8]1.[CH3:16][CH2:17][OH:18]>CCOC(C)=O>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([OH:8])[CH2:9][N:1]1[CH2:2][CH2:3][CH2:4][C@H:16]([C:17]([O:8][CH2:7][CH3:9])=[O:18])[CH2:6]1

Participants

4

Reactant 2

HCID 702EthanolHCID 53943982HCID 53943982, compound

Product 1

HCID 18665754HCID 18665754, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

2-(2-pyridyl)-2-phenyl oxirane (prepared following the procedure of Example 11, Step F) (0.106 g, 0.537 mmol) and S-(-)-ethyl nipecotate (0.093 g, 0.591 mmol) in EtOH (0.90 mL) were heated at 50° C. in a sealed tube with stirring for 24 hr. The reaction mixture was dissolved in EtOAc, washed with brine, dried (Na2SO4), filtered, and concentrated to dryness to give the title compound.

Workup

  1. washwashed with brine
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-169c9677562c4206bcdbc3ef94ba367e
Source dataset
uspto-grants-2000_10
Patent number
US06127366

Reaction notes

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