反应详情

1-(4-Cyanobenzyl)-5-(acetoxymethyl)-imidazole hydrobromide (50.4 g, 150 mmol) in 3:1 THF/water (1.5 L) at 0° C. was added lithium hydroxide monohydrate (18.9 g, 450 mmol). After 1 hr, the reaction was concentrated in vacuo, diluted with EtOAc (3 L), and washed with water, sat. aq. NaHCO3 and brine. The solution was then dried (Na2SO4), filtered, and concentrated in vacuo to provide the crude product as a pale yellow fluffy solid which was sufficiently pure for use in the next step without further purification.

1. concentrationthe reaction was concentrated in vacuo
2. additiondiluted with EtOAc (3 L)
3. washwashed with water, sat. aq. NaHCO3 and brine
4. dry with materialThe solution was then dried (Na2SO4)
5. filtrationfiltered
6. concentrationconcentrated in vacuo