Cyclohexylamine → HCID 19097440, compound

HRID 365471Notes

Reaction equation

HRID 365471 reaction equation
C([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9](Cl)=[N:10][CH:11]=1)=[O:5])C.[CH:13]1([NH2:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1>>[CH:13]1([NH:19][C:9]2[CH:8]=[CH:7][C:6]([C:4]([OH:3])=[O:5])=[CH:11][N:10]=2)[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1.[CH:13]1([NH-:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 2799611Ethyl 6-chloronicotinate

Product 2

HCID 19097440HCID 19097440, compoundHCID 232920546-(Cyclohexylamino)pyridine-3-carboxylic acid

Procedure

2-Chloro-5-pyridinecarboxylicacid ethylester (g,,5.0 mMol) was treated with 10 mMol cyclohexylamine and the mixture heated for 6 hours at 100° in a sealed tube. Preparative HPLC of the crude product gave the title compound along with equal amounts of the N-cyclohexylamide of the starting ester.

Workup

  1. temperaturethe mixture heated for 6 hours at 100° in a sealed tube

Sources & evidence

ORD record
ord-3d40e028299f4be9b5c1700f8943720b
Source dataset
uspto-grants-2000_10
Patent number
US06127390

Reaction notes

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