HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 10703303, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | HCID 10488190 | HCID 10488190 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 10703303 | HCID 10703303 | — |
Reaction Steps
A mixture composed of 2.57 g (13 mmol) of the nitrile obtained in Step 3, 120 ml of CH3OH, 2 g of Raney nickel and 50 ml of a solution of NH3 in CH3OH (7N) is hydrogenated under a pressure of one atmosphere for 16 hours. After filtration over Celite, the solution is concentrated and the residue is chromatographed on silica, eluting with a mixture of CH2Cl2 /CH3OH/NH4OH conc.=90/10/1, to yield the expected compound in the form of a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127396 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-bec7969c647e4059b52f0764cfb460c9 |
| Source note | uspto-grants-2000_10 |