反应详情

温度

20 °C

36.40 g (139 mmol) of triphenylphosphine are added, all at once and with vigorous stirring, to a solution, cooled to 0° C., of 10.40 g (70 mmol) of 2-hydroxymethyl-benzo[b]furan and 46 g (139 mol) of CBr4 in 220 ml of ether. After stirring for 4 hours at 20° C., the precipitate formed is suctioned off and washed with Et2O; the filtrate is dried and concentrated, and the residue is then chromatographed on silica, eluting with a mixture of cyclohexane/CH2Cl2 =80/20, to yield the expected compound in the form of an oil.

1. customthe precipitate formed
2. washwashed with Et2O
3. customthe filtrate is dried
4. concentrationconcentrated
5. customthe residue is then chromatographed on silica
6. washeluting with a mixture of cyclohexane/CH2Cl2 =80/20