HCID 17800145, compound → HCID 23292346, compound

HRID 365503Notes

Reaction equation

HRID 365503 reaction equation
[NH2:1][CH2:2][C:3]([NH:16][CH:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:18])([CH2:5][C:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=1)[CH3:4]>CCO>[NH2:1][CH2:2][C:3]([NH:16][CH:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH3:18])([CH3:4])[CH2:5][CH:6]1[CH2:15][CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1

Participants

3

Reactant 1

HCID 17800145HCID 17800145, compound

Product 1

HCID 23292346HCID 23292346, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 0.52 g (1.62 mmol) of the compound obtained in Step 2 (diastereoisomer 1) and of 0.1 g of Pd/Al2O3 in 60 ml of EtOH is hydrogenated at 20° C. under 1 bar for 16 hours. The mixture is then filtered and concentrated in vacuo to yield the title compound in the form of a foam.

Workup

  1. filtrationThe mixture is then filtered
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-2db60753db0c41bab30c4b94994d9d5d
Source dataset
uspto-grants-2000_10
Patent number
US06127396

Reaction notes

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