Formamidine acetate → HCID 23292298, compound

HRID 365505Notes

Reaction equation

HRID 365505 reaction equation
[C:1](O)(=O)[CH3:2].[CH:5]([NH2:7])=[NH:6].[C:8]([OH:15])(=[O:14])/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12]>CCO.CC(C)=O.C(O)(C)C>[C:8]([OH:15])(=[O:14])/[CH:9]=[CH:10]/[C:11]([OH:13])=[O:12].[NH:7]1[CH2:2][CH2:1][N:6]=[CH:5]1

Participants

6

Reactant 2

HCID 160693Formamidine acetateHCID 444972Fumaric Acid

Product 1

HCID 23292298HCID 23292298, compound

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 702EthanolSolventHCID 3776IsopropanolSolvent

Procedure

Formamidine acetate (654 mg, 6.3 mmol) is added to a solution of the compound obtained in Step 7 (1.5 g, 6.3 mmol) in EtOH (100 ml). After stirring for 14 hours at ambient temperature, the ethanol is evaporated off and the white solid is taken up in acetone (75 ml) and isopropanol (10 ml). The solution is filtered and fumaric acid (694 mg, 6.3 mmol), previously dissolved, with warming, in acetone (25 ml) and isopropanol (10 ml), is added. The title compound is obtained in the form of a solid, which is filtered off and dried in vacuo.

Workup

  1. customthe ethanol is evaporated off
  2. filtrationThe solution is filtered

Sources & evidence

ORD record
ord-40aee413697d4b228635b2f4183b7f9c
Source dataset
uspto-grants-2000_10
Patent number
US06127396

Reaction notes

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