Acetic Anhydride → HCID 10797410, compound

HRID 365558Notes

Reaction equation

HRID 365558 reaction equation
[CH3:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:6]([CH3:10])[C:3]=1[CH2:4][OH:5].[C:11](OC(=O)C)(=[O:13])[CH3:12]>CN(C)C1C=CN=CC=1>[C:11]([O:5][CH2:4][C:3]1[C:6]([CH3:10])=[CH:7][CH:8]=[CH:9][C:2]=1[CH3:1])(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 186748(2,6-Dimethylphenyl)methanol

Product 1

HCID 10797410HCID 10797410, compound

Reagents, catalysts & solvents 1

HCID 142844-(Dimethylamino)pyridineCatalyst

Conditions

Temperature
70 °C

Procedure

A mixture of 2,6-dimethylbenzyl alcohol (17.1 g) and acetic anhydride (14.2 ml) was stirred at 70° C. for 5 hours during which time to the mixture was added 4-dimethylaminopyridine (17 mg). After cooling, the reaction mixture was evaporated in vacuo. The residue was dissolved in ethyl acetate, and the solution was washed with water twice. The organic layer was dried over magnesium sulfate and evaporated in vacuo to give 2,6-dimethylbenzyl acetate (22.50 g) as colorless oil.

Workup

  1. temperatureAfter cooling
  2. customthe reaction mixture was evaporated in vacuo
  3. dissolutionThe residue was dissolved in ethyl acetate
  4. washthe solution was washed with water twice
  5. dry with materialThe organic layer was dried over magnesium sulfate
  6. customevaporated in vacuo

Sources & evidence

ORD record
ord-a669f198b4514b93bf64208e114dfc58
Source dataset
uspto-grants-2000_10
Patent number
US06127389

Reaction notes

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