反应详情

A mixture of 8-[2,6-dichloro-3-[N-methyl-N-(phthalimidoacetyl)amino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy)quinoline (750 mg), hydrazine monohydrate (117 mg) and ethanol was heated under reflex for 4 hours. The precipitate was removed by filtration and filtrate was evaporated in vacuo. The residue was dissolved with a mixture of chloroform and methanol (10:1, V/V), precipitate was removed by filtration and filtrate was evaporated in vacuo. The residue was purified by column chromatography on silica gel eluting with chloroform - methanol to afford 8-[3-(N-glycyl-N-methylamino)-2,6-dichlorobenzyloxy]-2-methyl-4-(2-pyridylmethoxy)quinoline (390 mg) as an amorphous powder.

1. temperaturewas heated under reflex for 4 hours
2. customThe precipitate was removed by filtration and filtrate
3. customwas evaporated in vacuo
4. dissolutionThe residue was dissolved with a mixture of chloroform and methanol (10:1, V/V), precipitate
5. customwas removed by filtration and filtrate
6. customwas evaporated in vacuo
7. customThe residue was purified by column chromatography on silica gel eluting with chloroform - methanol