HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acryloyl chloride → 1-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acryloyl chloride | HCID 13140 | — |
| Reactant | 7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine | HCID 11805628 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)prop-2-en-1-one | HCID 11391024 | 83% |
Reaction Steps
7-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (10.0 g) (refer to preparation examples 1 to 6 as mentioned below), triethylamine (10.2 g) and acryloyl chloride (6.9 g) were reacted in the same manner as in Experimental Example 1 to give 4-acryloyl-7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (10.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05416066 |
| Source dataset | uspto-grants-1995_05 |
| ORD ID | ord-1b2d35c60b474b09b20d181d46617d4d |
| Source note | uspto-grants-1995_05 |