Phenethylamine → HCID 4262649, compound

HRID 365644Notes

Reaction equation

HRID 365644 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[O:12])[O:10][C:8](=O)[C:7]2=[CH:13][CH:14]=1)([O-:3])=[O:2].[CH2:15]([NH2:23])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1(C)C=CC=CC=1>[C:17]1([CH2:16][CH2:15][N:23]2[C:11](=[O:12])[C:6]3=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:14][CH:13]=[C:7]3[C:8]2=[O:10])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 1001PhenethylamineHCID 2309764-Nitrophthalic acid anhydride

Product 1

HCID 4262649HCID 4262649, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4-nitrophthalic anhydride (18 g, 93.3 mmol) and phenethylamine (11.5 g, 95 mmol) in toluene (250 mL) was heated to reflux. After 2.5 h, the mixture was concentrated to solid residue, which was triturated and filtered to yield the title compound (24.5 g, 89%). Mp 142-30C.

Workup

  1. temperaturewas heated to reflux
  2. concentrationthe mixture was concentrated to solid residue, which
  3. customwas triturated
  4. filtrationfiltered

Sources & evidence

ORD record
ord-0b3561f716794176a17e9dd562fd7744
Source dataset
uspto-grants-2000_10
Patent number
US06127359

Reaction notes

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