Piperidine → 4-piperidin-1-ylbenzonitrile

HRID 365734Notes

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[N:10]1([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

Reactant 2

HCID 8082Piperidine

HCID 145174-Fluorobenzonitrile

Product 1

HCID 7667714-piperidin-1-ylbenzonitrile

Procedure

According to a similar manner to that in Reference Example 12, the title compound was synthesized from 4-fluorobenzonitrile and piperidine.

Sources & evidence

ORD record: ord-6e2de8def593469c8092d88d3f9e7ee4
Source dataset: uspto-grants-2000_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06127541

Reaction notes

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