Pyridine → HCID 53841341, compound

Temperature

0 °C

2.6 g (10 mmol) of 4-(N-tert-butyloxycarbonyl)amino-4-phenyl-2-butene-1-ol was added to a solution of 10 ml of 3N-HCl in ethyl acetate, and the mixture was stirred for 30 minutes. After adding 20 ml of H2O, the mixture was extracted with 30 ml of ethyl acetate. Then, a water layer was basified with potassium carbonate, extracted with 20 ml of methylene chloride twice, dried with MgSO4, filtered, and concentrated under reduced pressure, thereby obtaining 1.17 g (72% yield) of 4-amino-4-phenyl-2-butene-1-ol. Next, the product was added with 20 ml of methylene chloride, cooled to 0° C., and then added with 0.83 ml (7.17 mmol) of benzoyl chloride and 1.0 ml (7.17 mmol) of triethyl amine. After stirring for 1 hour, the mixture was added with 0.68 ml (7.17 mmol) of acetic anhydride and 0.58 ml (7.58 ml) of pyridine, and then further stirred for 24 hours. After the stirred solution was added with 20 ml of H2O, an organic layer was isolated, washed with 20 ml of 1N-HCl, 20 ml of a saturated aqueous solution of sodium carbonate, and then with 20 ml of brine, filtered, and then concentrated under reduced pressure. The concentrate was recrystallized from methylene chloride-hexane, thereby obtaining 2.17 g (98%) of 4-(N-benzoyl)amino-4-phenyl-1-acetoxy-2-butene.

1. stirringfurther stirred for 24 hours
2. customan organic layer was isolated
3. washwashed with 20 ml of 1N-HCl, 20 ml of a saturated aqueous solution of sodium carbonate
4. filtrationwith 20 ml of brine, filtered
5. concentrationconcentrated under reduced pressure
6. customThe concentrate was recrystallized from methylene chloride-hexane

ORD record

ord-f4d208a14be444d59867f9cb53396b7c

Source dataset

uspto-grants-2000_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06127546