Methanol → HCID 11255542, compound

HRID 365959Notes

Reaction equation

HRID 365959 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([CH3:16])=[CH:14][C:13]([O:17][CH3:18])=[C:12]([O:19][CH3:20])[C:11]=2[O:21][CH3:22])=[O:9])=[C:6]([O:23]C(=O)C(C)(C)C)[CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].CO>O>[CH3:1][C:2]1[C:7]([C:8]([C:10]2[C:15]([CH3:16])=[CH:14][C:13]([O:17][CH3:18])=[C:12]([O:19][CH3:20])[C:11]=2[O:21][CH3:22])=[O:9])=[C:6]([OH:23])[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 11430Potassium CarbonateHCID 11475070HCID 11475070, compound

Product 1

HCID 11255542HCID 11255542, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of 3B (1.42 g, 3.6 mmol), potassium carbonate (1.5 g), methanol (30 ml) and water (10 ml) is stirred at room temperature for 16 hours. The reaction mixture is poured into water, acidified and extracted with diisopropylether. The organic phase is separated and concentrated. The pure product is obtained as a yellow solid, 0.75 g (65.8%), mp. 82-84° C.

Workup

  1. extractionextracted with diisopropylether
  2. customThe organic phase is separated
  3. concentrationconcentrated
  4. customThe pure product is obtained as a yellow solid, 0.75 g (65.8%), mp. 82-84° C.

Sources & evidence

ORD record
ord-4048dd197fcf4be18fea400776c1d8f7
Source dataset
uspto-grants-2000_10
Patent number
US06127570

Reaction notes

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