反应详情

Prepared according to the method described in Example 1(a) above from Nα -Boc-Nδ -Cbz-(R)-ornithine (5.0 g; 13 mmol), BOP reagent (6.0 g; 13 mmol), HOBT (1.8 g; 13 mmol) and DiPEA (7.1 mL; 40.0 mmol) 100 mL of acetonitrile:CH2Cl2 (1:1), followed by 1.8 mL (13 mmol) of (R)-α-methylbenzylamine, then stirred overnight. After work up, the crude product was purified by passing it through a plug of silica gel with EtOAc to give 5.9 g (92%) of the sub-title compound as a light yellow solid.

1. customPrepared
2. customAfter work up, the crude product was purified