HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → (R)-N2-(Diphenylacetyl)-(S)-N-(1-phenylethyl)ornithine amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-N5-(Cbz)-N2-(diphenylacetyl)-(S)-N-(1-phenylethyl)ornithine amide | HCID 131722048 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N2-(Diphenylacetyl)-(S)-N-(1-phenylethyl)ornithine amide hydrochloride | HCID 131722046 | — |
Reaction Steps
Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(S)-N-(1-phenylethyl)ornithine amide (2.0 g; 3.5 mmol; from step (b) above), 10% Pd/C (w/w; 150 mg), HOAc (100 mL; instead of MeOH), overnight reaction time. The crude acetate salt was converted to the sub-title hydrochloride and was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-97a8e9324d2f40f4ac14d0bab09bf6f1 |
| Source note | uspto-grants-2000_10 |