Hydrochloric Acid → (R)-N2-(Diphenylacetyl)-(S)-N-[2-hydroxy-l-(4-methoxyphenyl)-ethyl]ornithine amide hydrochloride

Participants

Reaction Steps

Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(S)-N-[2-hydroxy-1 -(4-methoxyphenyl)-ethyl]ornithine amide (2.85 g; from step (c) above), 10% Pd/C (1.40 g), MeOH (200 mL) and concentrated HCl (2 mL) under hydrogen for 6 hours to give the crude product as a solid (2.6 g). Pure sub-title compound was obtained by crystallization from MeOH:diethyl ether to give a white solid (1.58 g).

Provenance & Evidence