HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (R)-N2-(Diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-ornithine amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-N5-(Cbz)-N2-(Diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxy-phenyl)ethyl]ornithine amide | HCID 131722078 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (R)-N2-(Diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]-ornithine amide hydrochloride | HCID 131722079 | — |
Reaction Steps
Prepared according to the method described in Example 1(e) above from (R)-N5 -(Cbz)-N2 -(diphenylacetyl)-(R)-N-[2-hydroxy-1-(4-methoxyphenyl)-ethyl]ornithine amide (0.63 g; from step (c) above), 10% Pd/C (0.30 g), MeOH (100 mL) and concentrated HCl (1 mL) under hydrogen, 18 hours reaction time to give the crude sub-title compound as a solid (0.57 g) which was used without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06127414 |
| Source dataset | uspto-grants-2000_10 |
| ORD ID | ord-971e0f117d4a45b0b6a6652b5da58681 |
| Source note | uspto-grants-2000_10 |